Tropoelastin
Tropoelastin
Human Tropoelastin, purified recombinant protein, lyophilized
For research applications, e.g. tissue engineering and cell culture.
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Tropoelastin is a highly flexible protein with alternating hydrophilic and hydrophobic domains. In humans, there are 13 isoforms known which are all derived from the ELN gene by alternative splicing. The molecular weight of these individual isoforms ranges from approx. 50 – 70 kDa.
Tropoelastin functions as the soluble precursor molecule of elastin. After its expression in the cell it is secreted and forms aggregates that become cross-linked and incorporated into growing elastic fibers.
With a half-life of >70 years elastin is a highly stable protein. Moreover, it is a fundamental component of the extracellular matrix (ECM) of tissues whose function requires flexibility (e.g. blood vessels, heart, lung or skin). Elastin provides elasticity and strength and enables these tissues to return to their original shape after being stretched. Besides that, elastin is also involved in wound healing.
Due to its immediate turnover into elastic fibers, native tropoelastin is not available in the cell and therefore cannot be purified from tissues. Using recombinant methods, we are able to provide human recombinant tropoelastin as sterile, lyophilized protein of high purity for research applications.