The CVD-Kit comprises of 4 QconCAT polypeptides covering 47 proteins with 212 peptides and is based on quantitative proteomics results of the TransCard project, a multidisciplinary research consortium of two SMEs and four academic partners studying the molecular origin of disturbed LDL, triglyceride and/or HDL metabolism, correlated with cardiovascular disease (CVD).
By selecting peptides that are shared between human, mouse and rat, the kit can be applied in studies empolying any of these prominent model organisms for CVD research.
CVDQuant
The Kit contains 4 heavy isotope labelled QconCAT proteins for 200 applications and the RePLiCal calibration standard for retention time normalization. The QconCAT proteins can be used individually, as mix or in combination with other reference standards.
The Kit contains:
Component Description PQ-CVD-1 QconCAT for high abundant proteins PQ-CVD-2 QconCAT for medium abundant proteins PQ-CVD-3 QconCAT for low abundant proteins PQ-CVD-4 QconCAT for low abundant proteins RePLiCal Calibration standard for retention time normalization Protein list:
PQ-CVD-1 PQ-CVD-2 PQ-CVD-3 PQ-CVD-4 APOA1 APOC4 MMP9 LPL APOB APOC1 ADAM17 LIPC CLU APOM EXT1 LIPG APOD CRP EXT2 ANGPTL2 PZP APOL1 NDST1 ANGPTL3 A2M APOF NDST2 ANGPTL4 APOA2 LCAT SULF1 ANGPTL8 APOE ADIPOQ SULF2 LDLR RBP4 APOC2 SDC1 LRP1 APOC3 PLTP GPD1 SCARB1 APOA4 CETP PCSK9 LBP APOA5 LPA HSPA5